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Aromatic amino acid hydroxylase inhibitors. 3. In vitro inhibition by azadopamine analogs L. E. Hare, M. C. Lu, C. B. Sullivan, P. T. Sullivan, R. E. Counsell, and P. A. Weinhold pp 1 - 5; DOI: 10.1021/jm00247a001 |
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Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines Howard J. Schaeffer and Charles F. Schwender pp 6 - 8; DOI: 10.1021/jm00247a002 |
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Synthesis and enzymic evaluation of some N-alkyl branched chain piperidine salts and N-alkyl-3-(N,N-diethylcarbamoyl)piperidine salts as inhibitors of acetyl- and butyrylcholinesterase James W. Stanley, Ian W. Mathison, and James G. Beasley pp 8 - 12; DOI: 10.1021/jm00247a003 |
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Synthesis and enzymic evaluation of pyridostigmine analogs used to probe the active sites of acetylcholinesterase and butyrylcholinesterase O. Elmo Millner, James W. Stanley, and William P. Purcell pp 13 - 18; DOI: 10.1021/jm00247a004 |
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Structure-activity relations in reactivators of organophosphorus-inhibited acetylcholinesterase. 7. 1-Aryl-2-hydroxyiminomethyl-3-methylimidazolium iodides Palmarisa Franchetti, Mario Grifantini, Sante Martelli, and Maria L. Stein pp 18 - 22; DOI: 10.1021/jm00247a005 |
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Sulfonamide structure-activity relations in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog Lothar Bock, George H. Miller, Klaus J. Schaper, and Joachim K. Seydel pp 23 - 28; DOI: 10.1021/jm00247a006 |
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Relation between .pi. and Rm values of sulfonamides Gian L. Biagi, Anna M. Barbaro, Maria C. Guerra, Giorgio C. Forti, and Maria E. Fracasso pp 28 - 33; DOI: 10.1021/jm00247a007 |
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Semisynthetic cephalosporins. Synthesis and structure-activity relations of 7-mandelamido-3-cephem-4-carboxylic acids J. R. E. Hoover, G. L. Dunn, D. R. Jakas, L. L. Lam, J. J. Taggart, J. R. Guarini, and L. Phillips pp 34 - 41; DOI: 10.1021/jm00247a008 |
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Differential effects of benzodioxane, chroman, and dihydrobenzofuran analogs of clofibrate on various parameters of hepatic drug metabolism Neil J. Lewis, Dennis R. Feller, Guiragos K. Poochikian, and Donald T. Witiak pp 41 - 45; DOI: 10.1021/jm00247a009 |
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Disposition and metabolism of 4-methyl-2-(4-phenylbenzyl)-2-oxazoline-4-methanol in the rat and dog Lennox B. Turnbull, Christopher P. Johnson, Ying Ho Chen, Lawrence F. Sancilio, and Robert B. Bruce pp 45 - 48; DOI: 10.1021/jm00247a010 |
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Adrenergic agents. 1. Synthesis and potential .beta.-adrenergic agonist activity of some catechol amine analogs bearing a substituted amino functionality in the meta position Carl Kaiser, Donald F. Colella, Mark S. Schwartz, Eleanor Garvey, and Joe R. Wardell pp 49 - 57; DOI: 10.1021/jm00247a011 |
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Analogs of phenothiazines. 5. Synthesis and neuropharmacological activity of some piperidylidene derivatives of thioxanthenes, xanthenes, dibenzoxepins, and acridans Carl Kaiser, Philip J. Fowler, David H. Tedeschi, Bruce M. Lester, Eleanor Garvey, Charles L. Zirkle, Edward A. Nodiff, and Andrew J. Saggiomo pp 57 - 62; DOI: 10.1021/jm00247a012 |
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Molecular structure and conformation of the nucleoside antibiotic derivative 2-methylformycin with a C-glycosidic bond Jaime E. Abola, Michael J. Sims, Donald J. Abraham, Arthur F. Lewis, and Leroy B. Townsend pp 62 - 65; DOI: 10.1021/jm00247a013 |
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Antidepressant agents. 1. Chemistry and pharmacology of amino-substituted spiro[5H-dibenzo[a,d]cycloheptene-5,1'-cycloalkanes] B. Carnmalm, E. Jacupovic, L. Johansson, T. De Paulis, S. Ramsby, N. E. Stjernstrom, A. L. Renyi, S. B. Ross, and S. O. Ogren pp 65 - 72; DOI: 10.1021/jm00247a014 |
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Aminoalkyldibenzo[a,e]cyclopropa[c]cycloheptene derivatives. Series of potent antidepressants W. E. Coyne and J. W. Cusic pp 72 - 75; DOI: 10.1021/jm00247a015 |
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Antimalarial drugs. 35. Synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-2-pyrimidinyl]guanidine and related substances Edward F. Elslager, Leslie M. Werbel, Ann Curry, Nancy Headen, and Judith Johnson pp 75 - 100; DOI: 10.1021/jm00247a016 |
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Synthesis of pivaloyloxymethyl 6-N'-cyanoamidinopenicillanates and the antibacterial activity of the corresponding acids Hans Jorgen Petersen pp 101 - 104; DOI: 10.1021/jm00247a017 |
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Antibacterial activity of 9(S)-erythromycylamine-aldehyde condensation products E. H. Massey, B. S. Kitchell, L. D. Martin, and K. Gerzon pp 105 - 107; DOI: 10.1021/jm00247a018 |
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Potential hypolipidemic agents. 7. Synthesis and lipid-lowering properties of 2-(dibenzofuranyloxy)-2-methylpropionates and related compounds Goran Bondesson, Christina Hedbom, Thomas Hogberg, Olle Magnusson, Nils E. Stjernstrom, and Lars A. Carlson pp 108 - 112; DOI: 10.1021/jm00247a019 |
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Synthesis of phosphoric acid isoesters of 2-phospho-, 3-phospho-, and 2,3-diphosphoglyceric acid Francis R. Pfeiffer, Jeanette D. Mier, and Jerry A. Weisbach pp 112 - 115; DOI: 10.1021/jm00247a020 |
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Monofluoromethanesulfonanilides. New series of bronchodilators E. H. Banitt, W. E. Coyne, K. T. McGurran, and J. E. Robertson pp 116 - 120; DOI: 10.1021/jm00247a021 |
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Synthesis of monoaryl- and diarylphosphorus analogs of methadone William H. Shelver, Martin Schreibman, N. Stevan Tanner, and V. Subba Rao pp 120 - 124; DOI: 10.1021/jm00247a022 |
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Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance James G. Henkel, Kevin H. Bell, and Philip S. Portoghese pp 124 - 129; DOI: 10.1021/jm00247a023 |
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Stereochemical studies on medicinal agents. 17. Synthesis, absolute configuration, and analgetic potency of enantiomeric diastereomers of 3-ethyl and 3-propyl derivatives of 1-methyl-4-phenyl-4-propionoxypiperidine Kevin H. Bell and Philip S. Portoghese pp 129 - 131; DOI: 10.1021/jm00247a024 |
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Analogs of phenothiazines. 6. Stereochemical assignment of isomeric aminoalkylidene derivatives of xanthenes and thioxanthenes with neuropharmacological activity Carl Kaiser, Richard J. Warren, and Charles L. Zirkle pp 131 - 133; DOI: 10.1021/jm00247a025 |
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Phenylmorphan agonists-antagonists Helen H. Ong, Tokuro Ohishi, and Everette L. May pp 133 - 134; DOI: 10.1021/jm00247a026 |
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Alkaloids in mammalian tissues. 4. Synthesis of (+)- and (-)-salsoline and isosalsoline Sidney Teitel, Jay O'Brien, William Pool, and Arnold Brossi pp 134 - 137; DOI: 10.1021/jm00247a027 |
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Synthesis and antibacterial activity of some substituted 4-quinolone-3-carboxylic acids D. G. Markees, Linda S. Schwab, and A. Vegotsky pp 137 - 139; DOI: 10.1021/jm00247a028 |
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Oral gold. Synthesis and antiarthritic properties of some large-ring gold chelates Joseph Weinstock, Blaine M. Sutton, George Y. Kuo, Donald T. Walz, and Michael J. DiMartino pp 139 - 140; DOI: 10.1021/jm00247a029 |
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Synthesis and biological properties of [2-L-.beta.-(pyrazolyl-3)alanine]-luteinizing hormone-releasing hormone David H. Coy, Esther J. Coy, Yoshihiro Hirotsu, and Andrew V. Schally pp 140 - 142; DOI: 10.1021/jm00247a030 |
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Potential antileprotic agents. 1. Inhibition of a model mycobacterial system by diaryl sulfones W. T. Colwell, G. Chan, V. H. Brown, J. I. DeGraw, J. H. Peters, and N. E. Morrison pp 142 - 144; DOI: 10.1021/jm00247a031 |
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Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase J. I. DeGraw, V. H. Brown, W. T. Colwell, and N. E. Morrison pp 144 - 146; DOI: 10.1021/jm00247a032 |
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Estrogenic triarylcyclopropanes G. R. Bedford, A. L. Walpole, and B. Wright pp 147 - 149; DOI: 10.1021/jm00247a033 |
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Book Reviews pp 149 - 149; DOI: 10.1021/jm00247a600 |
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Quantum statistical calculation for correlation of biological activity and chemical structure. 1. Drug-receptor interactions Teng K. Lin pp 151 - 154; DOI: 10.1021/jm00248a001 |
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Cycloalkanones. 3. Structure-activity relations of hypocholesterolemic cyclooctanone derivatives G. L. Carlson, I. H. Hall, G. S. Abernethy, and C. Piantadosi pp 154 - 157; DOI: 10.1021/jm00248a002 |
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Hansch analysis of the anabolic activities of some nandrolone esters Mohammad A. Q. Chaudry and Kenneth C. James pp 157 - 161; DOI: 10.1021/jm00248a003 |
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Potential psychotomimetics. 2. Rigid analogs of 2,5-dimethoxy-4-methylphenylisopropylamine (DOM, STP) David E. Nichols, Charles F. Barfknecht, John P. Long, Robert T. Standridge, Henry G. Howell, Richard A. Partyka, and Donald C. Dyer pp 161 - 166; DOI: 10.1021/jm00248a004 |
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Rigid analogs of indomethacin Douglas R. Olson, William J. Wheeler, and Jack N. Wells pp 167 - 171; DOI: 10.1021/jm00248a005 |
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.alpha.-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity Frederic A. French, Erwin J. Blanz, Sue C. Shaddix, and R. Wallace Brockman pp 172 - 181; DOI: 10.1021/jm00248a006 |
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Synthesis and biological activity of some 6,7-dihalo-.DELTA.5-pregnenes and some 6,6-dihalo-5,7-cyclo-5.beta.-pregnane derivatives Perry Rosen, Alfred Boris, and Robert Karasiewicz pp 182 - 184; DOI: 10.1021/jm00248a007 |
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Synthesis and biological activities of substituted glycyrrhetic acids John S. Baran, Donna D. Langford, Chi D. Liang, and Barnett S. Pitzele pp 184 - 191; DOI: 10.1021/jm00248a008 |
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Synthesis of 2-oxygenated glycyrrhetic acid derivatives Barnett S. Pitzele pp 191 - 194; DOI: 10.1021/jm00248a009 |
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Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity Michael Jarman, Leslie J. Griggs, and Michael J. Tisdale pp 194 - 197; DOI: 10.1021/jm00248a010 |
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1,4-Benzodioxanes as reversible and irreversible antagonists at adrenergic receptors B. P. Avner and D. J. Triggle pp 197 - 200; DOI: 10.1021/jm00248a011 |
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1-Alkylamino-3-(2-thiazolyloxy)-2-propanols. Novel class of mixed myocardial .beta.-stimulants/.beta.-blockers J. A. Edwards, B. Berkoz, G. S. Lewis, O. Halpern, J. H. Fried, A. M. Strosberg, L. M. Miller, S. Urich, F. Liu, and A. P. Roszkowski pp 200 - 203; DOI: 10.1021/jm00248a012 |
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Furazanobenzofuroxan, furazanobenzothiadiazole, and their N-oxides. New class of vasodilator drugs Peter B. Ghosh and Barry J. Everitt pp 203 - 206; DOI: 10.1021/jm00248a013 |
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Antiparasitic 5-nitrothiazoles and 5-nitro-4-thiazolines. 4 Peter J. Islip, Michael D. Closier, and Martin C. Neville pp 207 - 209; DOI: 10.1021/jm00248a014 |
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Optical isomers of aryl-2-piperidylmethanol antimalarial agents. Preparation, optical purity, and absolute stereochemistry F. I. Carroll and J. T. Blackwell pp 210 - 219; DOI: 10.1021/jm00248a015 |
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Folic acid analogs. Modifications in the benzene-ring region. 4. 3'-Ethyl- and 3'-isopropylfolic acids Eugene C. Roberts and Y. Fulmer Shealy pp 219 - 222; DOI: 10.1021/jm00248a016 |
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Synthesis and biological evaluation of isofolic acid M. G. Nair and Charles M. Baugh pp 223 - 226; DOI: 10.1021/jm00248a017 |
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Syntheses and biological activities of 7-ethyl-8-bromo-10-(1'-D-ribityl)isoalloxazine and 7-bromo-8-ethyl-10-(1'-D-ribityl)isoalloxazine, analogs riboflavine John P. Lambooy pp 227 - 230; DOI: 10.1021/jm00248a018 |
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Synthetic luteinizing hormone releasing factor. Short chain analogs J. Rivier, M. Amoss, C. Rivier, and W. Vale pp 230 - 233; DOI: 10.1021/jm00248a019 |
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Adrenocorticotropin. 45. Synthesis and steroidogenic activity of [1-alanine]-adrenocorticotropin-(1-20)-amide, [1-D-alanine]-adrenocorticotropin-(1-20)-amide, and [1-alanine-14C]-adrenocorticotropin-(1-20)-amide James Blake and Choh Hao Li pp 233 - 235; DOI: 10.1021/jm00248a020 |
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Hydrolysis of diacetylcycloserine. In vitro and in vivo studies John Charles Howard, James C. McPherson, and Augustine H. L. Chuang pp 236 - 238; DOI: 10.1021/jm00248a021 |
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Angiotensin-like and antagonistic activities of N-terminal modified [8-leucine]-angiotensin II peptides Therezinha B. Paiva, Gilberto Goissis, Luiz Juliano, Maria E. Miyamoto, and Antonio C. M. Paiva pp 238 - 241; DOI: 10.1021/jm00248a022 |
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Synthesis and anti-deoxyribonucleic acid virus activity of certain 9-.beta.-D-arabinofuranosyl-2-substituted adenine derivatives Kenji Miyai, Lois B. Allen, John H. Huffman, Robert W. Sidwell, and Richard L. Tolman pp 242 - 244; DOI: 10.1021/jm00248a023 |
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Synthesis and antifungal properties of 3-substituted as-triazino[5,6-c]quinolines George C. Wright, Joseph E. Gray, and Chia-Nien Yu pp 244 - 246; DOI: 10.1021/jm00248a024 |
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Radiopharmaceuticals. 12. New rapid synthesis of carbon-11-labeled norepinephrine hydrochloride Joanna S. Fowler, Robert R. MacGregor, Azizullah N. Ansari, Harold L. Atkins, and Alfred P. Wolf pp 246 - 248; DOI: 10.1021/jm00248a025 |
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Saligenin analogs of L-Dopa and DL-.alpha.-methyl-Dopa Michael Atkinson, David Hartley, Lawrence H. C. Lunts, and Alexander C. Ritchie pp 248 - 249; DOI: 10.1021/jm00248a026 |
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5-Hydroxy-5-phenyllevulinic acid. Novel microbial metabolite with analgesic activity E. R. Wetzel, A. C. Osterberg, and D. B. Borders pp 249 - 250; DOI: 10.1021/jm00248a027 |
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[1-.beta.-Mercapto-.beta.,.beta.-diethylpropionic acid]-8-lysine-vasopressin, a potent inhibitor of 8-lysine-vasopressin and of oxytocin Douglas F. Dyckes, John J. Nestor, Martha F. Ferger, and Vincent Du Vigneaud pp 250 - 252; DOI: 10.1021/jm00248a028 |
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Synthesis and some pharmacological properties of 8-.epsilon.-hydroxynorleucine-vasopressin Patricia Dreyfuss pp 252 - 255; DOI: 10.1021/jm00248a029 |
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4(1H)-Quinolones. 2. Antimalarial effect of some 2-methyl-3-(1-alkenyl- or -3-alkyl-4(1H)-quinolones Adria C. Casey pp 255 - 256; DOI: 10.1021/jm00248a030 |
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Book Reviews pp 257 - 258; DOI: 10.1021/jm00248a600 |
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Synthesis and biological activity of 9-.beta.-D-arabinofuranosyladenine cyclic 3',5'-phosphate and 9-.beta.-D-arabinofuranosylguanine cyclic 3',5'-phosphate A. Mohsin Mian, Richard Harris, Robert W. Sidwell, Roland K. Robins, and Tasneem A. Khwaja pp 259 - 263; DOI: 10.1021/jm00249a001 |
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Synthesis and antitumor activity of .alpha.- and .beta.-2'-deoxy-6-selenoguanosine and certain related derivatives George H. Milne and Leroy B. Townsend pp 263 - 268; DOI: 10.1021/jm00249a002 |
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5-Alkylpyrimidine nucleosides. Preparation and properties of 5-ethyl-2'-deoxycytidine and related nucleosides T. Kulikowski and D. Shugar pp 269 - 273; DOI: 10.1021/jm00249a003 |
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6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. Series of hypotensive agents William V. Curran and Adma Ross pp 273 - 281; DOI: 10.1021/jm00249a004 |
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6-(Substituted phenyl)-5-substituted-4,5-dihydro-3(2H)-pyridazinones. Antihypertensive agents Francis J. McEvoy and George R. Allen pp 281 - 286; DOI: 10.1021/jm00249a005 |
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Benzoxocin and benzoxonin derivatives. Novel groups of terpenophenols with central nervous system activity Shlomo Houry, Raphael Mechoulam, Philip J. Fowler, Edward Macko, and Bernard Loev pp 287 - 293; DOI: 10.1021/jm00249a006 |
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Benzodiazepines. 4. 2-Oxyamino-5-phenyl-3-H-1,4-benzodiazepines Jackson Hester and Allan D. Rudzik pp 293 - 295; DOI: 10.1021/jm00249a007 |
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Alkaloid studies. 9. Preparation of 18-acylyohimban-17-ones and their conversion to new heterocyclic yohimbans J. Donald Albright and Leon Goldman pp 296 - 300; DOI: 10.1021/jm00249a008 |
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Ergot alkaloids. Ergolines and related compounds as inhibitors of prolactin release John M. Cassady, George S. Li, Ernest B. Spitzner, Heinz G. Floss, and James A. Clemens pp 300 - 307; DOI: 10.1021/jm00249a009 |
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Inhibition of prolactin by ergoline congeners Charles F. Barfknecht, David B. Rusterholz, and Jonathan A. Parsons pp 308 - 312; DOI: 10.1021/jm00249a010 |
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Descarboxylysergic acid (9,10-didehydro-6-methylergoline) Nicholas J. Bach, David A. Hall, and Edmund C. Kornfeld pp 312 - 314; DOI: 10.1021/jm00249a011 |
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Synthesis and biological activity of some analogs of the gonadotropin releasing hormone W. Arnold, G. Flouret, R. Morgan, R. Rippel, and W. White pp 314 - 319; DOI: 10.1021/jm00249a012 |
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Antigenic determinants of the polypeptide, poly(L-tyrosyl-L-glutamyl-L-alanylglycyl)glycine-1-14C ethyl ester Brian J. Johnson and Charles Cheng pp 320 - 322; DOI: 10.1021/jm00249a013 |
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Angiotensin II analogs. 11. Des-aspartyl-angiotensin II Eugene C. Jorgensen, Ilona C. Kiraly-Olah, Thomas C. Lee, and Graham C. Windridge pp 323 - 326; DOI: 10.1021/jm00249a014 |
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Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid William W. Lee, Abelardo P. Martinez, and Leon Goodman pp 326 - 330; DOI: 10.1021/jm00249a015 |
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Structure activity relations. 7. Structure-activity relations of fenamic acids Hiroshi Terada, Saburo Muraoka, and Toshio Fujita pp 330 - 334; DOI: 10.1021/jm00249a016 |
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Synthesis and biological evaluation of some 14-O-acyl derivatives of adriamycin Federico Arcamone, Giovanni Franceschi, Anacleto Minghetti, Sergio Penco, Silvio Redaelli, Aurelio DiMarco, Anna M. Casazza, Teresa Dasdia, and Giovianna DiFronzo pp 335 - 337; DOI: 10.1021/jm00249a017 |
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Steroidal imidazole-1-carboxylic acid esters Kenneth E. Fahrenholtz, Alfred Boris, Thomas W. Kennedy, and R. W. Kierstead pp 337 - 342; DOI: 10.1021/jm00249a018 |
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CNDO [complete neglect of differential overlap]/2 study of the antibacterial activity of penicillins and cephalosporins W. C. Topp and B. G. Christensen pp 342 - 347; DOI: 10.1021/jm00249a019 |
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Experimental antileukemic agents. Coralyne, analogs, and related compounds Kwang-Yuen Zee-Cheng, Kenneth D. Paull, and C. C. Cheng pp 347 - 351; DOI: 10.1021/jm00249a020 |
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9,11-Seco steroids. Attempt to separate biological activities via ring cleavage Leland J. Chinn, John H. Dygos, Stanley E. Mares, Richard L. Aspinall, and Robert E. Ranney pp 351 - 354; DOI: 10.1021/jm00249a021 |
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1,6-Diammonium-2,4-hexadiyne analogs of hexamethonium Joseph G. Cannon, Lester E. Johnson, John Paul Long, and Sharon Heintz pp 355 - 358; DOI: 10.1021/jm00249a022 |
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Use of sodium cyanoborohydride in the preparation of biologically active nitroxides Gerald M. Rosen pp 358 - 360; DOI: 10.1021/jm00249a023 |
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2'-0-Methyl ether of 1-.beta.-D-arabinofuranosylcytosine John A. Montgomery and Anne G. Laseter pp 360 - 361; DOI: 10.1021/jm00249a024 |
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Antiviral agents. 1-Aralkyloxyadenosines W. M. Shannon, A. Shortnacy, G. Arnett, and J. A. Montgomery pp 361 - 363; DOI: 10.1021/jm00249a025 |
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Isosteres of natural phosphates. 2. Synthesis of the monosodium salt of 4-hydroxy-3-oxobutyl-l-phosphonic acid an isostere of dihydroxyacetone phosphate Stephen L. Goldstein, Diza Braksmayer, Burton E. Tropp, and Robert Engel pp 363 - 364; DOI: 10.1021/jm00249a026 |
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Cyclization of lactamimide ketones to imidazo[1,2-.alpha.]azacycloalkanes with hypoglycemic activity George P. Claxton, J. Martin Grisar, and Norbert L. Wiech pp 364 - 367; DOI: 10.1021/jm00249a027 |
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Aryl 5-nitro-2-furyl ketone antifungal agents S. S. Pelosi and J. E. Gray pp 367 - 369; DOI: 10.1021/jm00249a028 |
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Synthesis of 7H-pyrimido [4,5-b] [1,4] thiazines related to 7,8-dihydropteridines of biological importance Young Ho Kim and Henry G. Mautner pp 369 - 371; DOI: 10.1021/jm00249a029 |
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Total synthesis and resolution of terreic acid John C. Sheehan and Young S. Lo pp 371 - 372; DOI: 10.1021/jm00249a030 |
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Synthesis of 2,4-diamino-5-[4-arylthiophenyl]-and 5-[4-arylsulfonylphenyl]pyrimidines as antimalarials Bijan P. Das and David W. Boykin pp 372 - 374; DOI: 10.1021/jm00249a031 |
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Quinazolines and 1,4-benzodiazepines. 64. Comparison of the stereochemistry of diazepam with that of close analogs with marginal biological activity Leo H. Sternbach, Fred D. Sancilio, and John F. Blount pp 374 - 377; DOI: 10.1021/jm00249a032 |
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Determination of the absolute configuration of (+)-2-(6-methoxy-2-naphthyl)propionic acid J. Riegl, M. L. Maddox, and I. T. Harrison pp 377 - 378; DOI: 10.1021/jm00249a033 |
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Anticonvulsant activity of substituted Indolealkylamines V. K. Agarwal, A. K. Chaturvedi, T. K. Gupta, Surendra S. Parmar, and Benjamin De Boer pp 378 - 380; DOI: 10.1021/jm00249a034 |
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Identification of two metabolites of hydralazine from human urine Sylvai B. Zak, Thomas G. Gilleran, Jerrold Karliner, and George Lukas pp 381 - 382; DOI: 10.1021/jm00249a035 |
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Book Reviews pp 382 - 382; DOI: 10.1021/jm00249a600 |
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Diarylcyclobutane analogs of diethylstilbestrol John E. Lawson, Ronnie D. Dennis, Robert F. Majewski, and Duane G. Gallo pp 383 - 386; DOI: 10.1021/jm00250a001 |
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Synthesis, estrogenic activity, and electrophilic reactivity of an N-acetoxy-N-acetamido analog of diethylstilbestrol Helmut Bartsch, Mark Dworkin, James A. Miller, and Elizabeth C. Miller pp 386 - 389; DOI: 10.1021/jm00250a002 |
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Total synthesis of bisnorpenicillin V Jos Hoogmartens, Paul J. Claes, and Hubert Vanderhaeghe pp 389 - 392; DOI: 10.1021/jm00250a003 |
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New streptozotocin analogs with improved antileukemic activity Allan N. Fujiwara, Edward M. Acton, and David W. Henry pp 392 - 396; DOI: 10.1021/jm00250a004 |
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Oximes of 3-formylrifamycin SV. Synthesis, antibacterial activity, and other biological properties Renato Cricchio, Giancarlo Lancini, Giovanni Tamborini, and Piero Sensi pp 396 - 403; DOI: 10.1021/jm00250a005 |
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Synthesis, chemistry, and biological activity of 5-thiocyanatopyrimidine nucleosides as potential masked thiols Tomoako Nagamachi, Jean L. Fourrey, Paul F. Torrence, James A. Waters, and Bernhard Witkop pp 403 - 406; DOI: 10.1021/jm00250a006 |
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Synthesis and biological activity of some 8-substituted seleno cyclic nucleotides and related compounds Shih-Hsi Chu, Chyng-Yann Shiue, and Ming-Yu Chu pp 406 - 409; DOI: 10.1021/jm00250a007 |
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Discriminant analysis of the relation between physical properties and the inhibition of monoamine oxidase by aminotetralins and aminoindans Yvonne C. Martin, James B. Holland, Charles H. Jarboe, and Nicholas Plotnikoff pp 409 - 413; DOI: 10.1021/jm00250a008 |
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Mouse liver glyoxalase I inhibition by S-substituted glutathiones Marian V. Kester, Jon A. Reese, and Scotty J. Norton pp 413 - 416; DOI: 10.1021/jm00250a009 |
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Optically active amines. XV. Action of (S)- and (R)-para-substituted amphetamine hydrochlorides and (.alpha.S)- and (.alpha.R)-p-chloronorephedrine and (.alpha.S)- and (.alpha.R)-p-chloronorpseudoephedrine hydrochlorides on the level of 5-hydroxytryptamine and the activity of tryptophan hydroxylase in rat brain Howard E. Smith, Elizabeth P. Burrows, Jeffrey D. Miano, Charles D. Mount, Elaine Sanders-Bush, and Fridolin Sulser pp 416 - 421; DOI: 10.1021/jm00250a010 |
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Synthesis and antireserpine activity of peptides of L-dopa Arthur M. Felix, Donald P. Winter, Su-Sun Wang, Irina D. Kulesha, William R. Pool, Dorothy L. Hane, and Herbert Sheppard pp 422 - 426; DOI: 10.1021/jm00250a011 |
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.alpha.-Methyldopamine derivatives. Synthesis and pharmacology Robert J. Borgman, Michael R. Baylor, Joseph J. McPhillips, and Robert E. Stitzel pp 427 - 430; DOI: 10.1021/jm00250a012 |
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Synthesis of analogs of [8-isoleucine]angiotensin II with variations in position 1 Mahesh C. Khosla, Madeline M. Hall, Robert R. Smeby, and F. Merlin Bumpus pp 431 - 433; DOI: 10.1021/jm00250a013 |
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Thyroxine analogs. 22. Thyromimetic activity of halogen-free derivatives of 3,5-dimethyl-L-thyronine Eugene C. Jorgensen, Wallace J. Murray, and Paul Block pp 434 - 439; DOI: 10.1021/jm00250a014 |
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Molecular orbital studies on the conformation of hallucinogenic indolealkylamines and related compounds. Isolated molecules and the solvent effect B. Pullman, Ph. Courriere, and H. Berthod pp 439 - 447; DOI: 10.1021/jm00250a015 |
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Inhibitors of polyamine biosynthesis. 1. .alpha.-Methyl-(+-)-ornithine, an inhibitor of ornithine decarboxylase Mahmoud M. Abdel-Monem, Nancy E. Newton, and Charles E. Weeks pp 447 - 451; DOI: 10.1021/jm00250a016 |
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Nitrofurfuryl heterocycles. 12. 4-Amino-6-(5-nitro-2-furyl)isoxazolo[5,4-d]pyrimidines and 4-amino-2-(5-nitro-2-furyl)pyrimido[4,5-d]pyrimidines Homer A. Burch, Louis E. Benjamin, H. Eric Russell, and Raymond Freedman pp 451 - 453; DOI: 10.1021/jm00250a017 |
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Structure-activity studies on narcotic antagonists. 1. N-Substituted ethyl 3-phenylpyrrolidine-3-carboxylates and ethyl 3-phenylnipecotates Ronald L. Jacoby, Karl A. Nieforth, and Robert E. Willette pp 453 - 455; DOI: 10.1021/jm00250a018 |
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Cyclopentane analog of muscarone Fulvio Gualtieri, Mario Giannella, Carlo Melchiorre, and Maria Pigini pp 455 - 457; DOI: 10.1021/jm00250a019 |
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Carbocyclic analogs of muscarine. Oxidation of desethermuscarine to desethermuscarone Richard S. Givens and Donald R. Rademacher pp 457 - 459; DOI: 10.1021/jm00250a020 |
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Synthesis and central nervous system activity of 1,2,3,4-tetrahydro-1-amino-4-phenylnaphthalenes Lewis A. Walter, Wei K. Chang, Joanne Kenney, and Irina D. Kulecha pp 459 - 463; DOI: 10.1021/jm00250a021 |
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Synthesis and pharmacological properties of 5a,6,7,8,9,10,10a,11-octahydrobenzo[b]cyclohepta[e][1,4]thiazine derivatives Franco M. Moracci, Felice Liberatore, Paolo Marchini, Gaetano Liso, and Mario Cardellini pp 463 - 465; DOI: 10.1021/jm00250a022 |
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Procedure for preparing tritium-labeled tertiary amines. Synthesis of endo-etheno-6,7,8,14-tetrahydrooripavine-6,14-3H derivatives John W. Lewis, Michael J. Rance, and G. Raymond Young pp 465 - 466; DOI: 10.1021/jm00250a023 |
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Synthesis and biological activity of 2'-amino-2'-deoxy-5-fluorouridine R. A. Sharma, M. Bobek, and A. Bloch pp 466 - 468; DOI: 10.1021/jm00250a024 |
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Antimalarials. 2. .alpha.-Di-n-butylaminomethyl-2-(p-chlorophenyl)-5-quinazolinemethanol Philip A. Cruickshank and William E. Hymans pp 468 - 469; DOI: 10.1021/jm00250a025 |
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Antimicrobial activity of 8-deazafolic acid Joseph I. DeGraw, Roy L. Kisliuk, Yvette Gaumont, and Charles M. Baugh pp 470 - 471; DOI: 10.1021/jm00250a026 |
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Histamine N-methyltransferase. Inhibition and potentiation by trans- and cis-1,5-diphenyl-3-dimethylaminopyrrolidine Patrick E. Hanna and Ronald T. Borchardt pp 471 - 473; DOI: 10.1021/jm00250a027 |
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Synthesis of some trinucleoside monophosphates of biological interest Eric J. Norman and Joseph Nagyvary pp 473 - 475; DOI: 10.1021/jm00250a028 |
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9-Nor-.DELTA.8-tetrahydrocannabinol, a cannabinoid of metabolic interest Raymond S. Wilson and Everette L. May pp 475 - 476; DOI: 10.1021/jm00250a029 |
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Book Reviews pp 476 - 476; DOI: 10.1021/jm00250a600 |
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Quantitative structure-activity relations in anticancer agents. Activity of selected nitrosoureas against a solid tumor, the Lewis lung carcinoma John A. Montgomery, Joseph G. Mayo, and Corwin Hansch pp 477 - 480; DOI: 10.1021/jm00251a001 |
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Antifilarial agents. Diazabicyclooctanes and diazabicycloheptanes as bridged analogs of diethylcarbamazine Priscilla A. Sturm, David W. Henry, P. E. Thompson, J. B. Zeigler, and J. W. McCall pp 481 - 487; DOI: 10.1021/jm00251a002 |
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2,4,5-Trimethylpyrrole-3-carboxylic acid esters of various alkaloids James A. Waters, Cyrus R. Creveling, and Bernhard Witkop pp 488 - 491; DOI: 10.1021/jm00251a003 |
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New nonsteroidal antiinflammatory agent. 3. Analogs of 2-substituted 5-benzothiazoleacetic acids and their derivatives Hiroki Miyamatsu, Shinji Ueno, Mitsuhiro Shimizu, Jinichi Hosono, Masazumi Tomari, Keiichi Seida, Tadayuki Suzuki, and Jin Wada pp 491 - 496; DOI: 10.1021/jm00251a004 |
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Quinuclidine chemistry. 2. Synthesis and antiinflammatory properties of 2-substituted benzhydryl-3-quinuclidinols E. J. Warawa, N. J. Mueller, and R. Jules pp 497 - 501; DOI: 10.1021/jm00251a005 |
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Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol Carlo Petrongolo, Jacopo Tomasi, Bruno Macchia, and Franco Macchia pp 501 - 507; DOI: 10.1021/jm00251a006 |
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.beta.-Adrenoceptor studies. 1. In vitro .beta.-adrenergic blocking, antiarrhythmic, and local anesthetic activities of a new series of aromatic bis(2-hydroxy-3-isopropylaminopropyl) ethers J. Zaagsma and W. Th. Nauta pp 507 - 513; DOI: 10.1021/jm00251a007 |
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Bronchodilators giving reduced cardiovascular effects. Relative biological activities of the four isomers of 1-(3,4-dihydroxyphenyl)-2-isopropylaminobutanol Michael J. Mardle, Harry Smith, Barbara A. Spicer, and Robert H. Poyser pp 513 - 516; DOI: 10.1021/jm00251a008 |
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Naphthothiophenes. 4. Preparation of multisubstituted 4-naphtho[2,1-b]thiophenemethanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho[2,1-b] thiophenemethanols Bijan P. Das, Merrill E. Nuss, and David W. Boykin pp 516 - 519; DOI: 10.1021/jm00251a009 |
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Antimalarials. 6. Synthesis, antimalarial activity, and configurations of racemic .alpha.-(2-piperidyl)-4-pyridinemethanols M. P. LaMontagne, A. Markovac, and P. Blumbergs pp 519 - 523; DOI: 10.1021/jm00251a010 |
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Substituent effects upon the base hydrolysis of penicillins and cephalosporins. Competitive intramolecular nucleophilic amino attack in cephalosporins Joseph M. Indelicato, Theresa T. Norvilas, Ralph R. Pfeiffer, William J. Wheeler, and William L. Wilham pp 523 - 527; DOI: 10.1021/jm00251a011 |
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Effect of 6-.alpha. substitution in penicillins and 7-.alpha. substitution in cephalosporins upon .beta.-lactam reactivity Joseph M. Indelicato and William L. Wilham pp 528 - 529; DOI: 10.1021/jm00251a012 |
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Derivatives of 3,4-dihydrocarbostyril as .beta.-adrenergic blocking agents Kazuyuki Nakagawa, Nanami Murakami, Shiro Yoshizaki, Michiaki Tominaga, Hideo Mori, Youichi Yabuuchi, and Shigeyuki Shintani pp 529 - 533; DOI: 10.1021/jm00251a013 |
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Substructural analysis. Novel approach to the problem of drug design Richard D. Cramer, George Redl, and Charles E. Berkoff pp 533 - 535; DOI: 10.1021/jm00251a014 |
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Preparation and antitumor activity of 4'-thio analogs of 2,2'-anhydro-1-.beta.-D-arabinofuranosylcytosine N. Ototani and Roy L. Whistler pp 535 - 537; DOI: 10.1021/jm00251a015 |
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Hydroxyproline analogs of bradykinin John Morrow Stewart, James W. Ryan, and A. H. Brady pp 537 - 539; DOI: 10.1021/jm00251a016 |
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Analogs of the abortifacient aminoglutethimide Rolf Paul, Richard P. Williams, and Elliott Cohen pp 539 - 541; DOI: 10.1021/jm00251a017 |
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.beta.-Lactams. 35. Antibacterial activity of monocyclic .beta.-lactams Ajay K. Bose, M. S. Manhas, J. C. Kapur, S. D. Sharma, and S. G. Amin pp 541 - 544; DOI: 10.1021/jm00251a018 |
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Synthesis and antiinflammatory activity of a series of 2-aroyl-1,1a,2,6b-tetrahydrocycloprop[b]indole-1-carboxylic acids William J. Welstead, Harold F. Stauffer, and Lawrence F. Sancilio pp 544 - 547; DOI: 10.1021/jm00251a019 |
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Efficient and selective method for the synthesis of 2-(4-fluorophenyl)-1-(2-hydroxyethyl)-5-nitroimidazole (flunidazole) Edward J. J. Grabowski, Thomas M. H. Liu, Ludwig Salce, and Erwin F. Schoenewaldt pp 547 - 549; DOI: 10.1021/jm00251a020 |
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Synthesis and biological properties of 5-aryl-4H-1,2,4-thiadiazine 1,1-dioxides W. L. Matier, W. T. Comer, and A. W. Gomoll pp 549 - 552; DOI: 10.1021/jm00251a021 |
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Synthesis and antifolate activity of 10-deazaminopterin Joseph I. DeGraw, Roy L. Kisliuk, Yvette Gaumont, Charles M. Baugh, and M. G. Nair pp 552 - 553; DOI: 10.1021/jm00251a022 |
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Synthesis of 1-deaza-N10-methylfolic acid and related compounds Robert D. Elliott, Carroll Temple, and John A. Montgomery pp 553 - 555; DOI: 10.1021/jm00251a023 |
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Ethambutol. Synthesis of an unsaturated analog Luigi Bernardi, Maurizio Foglio, and Aldemio Temperilli pp 555 - 556; DOI: 10.1021/jm00251a024 |
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Synthesis of pure p-chlorophenyl-L-alanine form L-phenylalanine Richard A. Houghten and Henry Rapoport pp 556 - 558; DOI: 10.1021/jm00251a025 |
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Potential bioreductive alkylating agents. 3. Synthesis and antineoplastic activity of acetoxymethyl and corresponding ethyl carbamate derivatives of benzoquinones Ai Jeng Lin, Charles W. Shansky, and Alan C. Sartorelli pp 558 - 561; DOI: 10.1021/jm00251a026 |
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Heterocyclic steroids. 5. Sulfur, selenium, and tellurium 5.alpha.-androstane derivatives and their 7.alpha.-methylated congeners Galal Zanati, Gunhild Gaare, and Manfred E. Wolff pp 561 - 563; DOI: 10.1021/jm00251a027 |
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Synthesis and antimalarial activity of anthracene amino alcohols Eugene L. Stogryn pp 563 - 565; DOI: 10.1021/jm00251a028 |
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Rigid amino acids related to .alpha.-methyldopa Joseph G. Cannon, John P. O'Donnell, John P. Rosazza, and Charles R. Hoppin pp 565 - 568; DOI: 10.1021/jm00251a029 |
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Book Reviews pp 568 - 568; DOI: 10.1021/jm00251a600 |
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Hypothalamic hormones. 55. Analogs of the luteinizing hormone-releasing hormone to study conformational aspects of the aromatic amino acid moieties and inhibition John Humphries, George Fisher, Yieh-Ping Wan, Karl Folkers, and Cyril Y. Bowers pp 569 - 571; DOI: 10.1021/jm00252a001 |
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Aminobenzoic acid diuretics. 6. 4-Substituted 3-alkylthio-5-sulfamoylbenzoic and 5-sulfamoylthiosalicylic acids Peter W. Feit, Ole B. Tvaermose Nielsen, and Herta Bruun pp 572 - 578; DOI: 10.1021/jm00252a002 |
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Puromycin analogs. Ribosomal binding with diastereomeric carbocyclic puromycin analogs Robert Vince and Susan Daluge pp 578 - 583; DOI: 10.1021/jm00252a003 |
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Ab initio calculations on large molecules using molecular fragments. Lincomycin model studies Lester L. Shipman, Ralph E. Christoffersen, and B. Vernon Cheney pp 583 - 590; DOI: 10.1021/jm00252a004 |
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Ab initio calculations on large molecules using molecular fragments. Structural correlations between natural substrate moieties and some antibiotic inhibitors of peptidyl transferase B. Vernon Cheney pp 590 - 599; DOI: 10.1021/jm00252a005 |
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Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata Ronald E. Betts, David E. Walters, and John P. Rosazza pp 599 - 602; DOI: 10.1021/jm00252a006 |
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Chemistry of adamantane. VII. Adamantanealkanamines as potential antidepressant and anti-Parkinson agents Jiban K. Chakrabarti, Michael J. Foulis, Terrence M. Hotten, Stephen S. Szinai, and Alec Todd pp 602 - 609; DOI: 10.1021/jm00252a007 |
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Synthesis and structure-activity relations of a series of antibacterially active 5-(5-nitro-2-furfurylidene)thiazolones, 5-(5-nitro-2-furylpropenylidene)thiazolones, and 6-(5-nitro-2-furyl)-4H-1,3-thiazinones Eva B. Akerblom pp 609 - 615; DOI: 10.1021/jm00252a008 |
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Synthesis of potential antimalarial agents. Preparation of some 6-amino-5,8-dimethoxyquinolines and the corresponding 6-amino-5,8-quinolinediones Carroll Temple, Jerry D. Rose, and John A. Montgomery pp 615 - 619; DOI: 10.1021/jm00252a009 |
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8-(.omega.-Aminoalkylamino)quinolines as potential prophylactic antimalarials William P. Wetter and C. DeWitt Blanton pp 620 - 624; DOI: 10.1021/jm00252a010 |
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Synthesis and pharmacological evaluation of 2,3-dihydro-1H-thieno[2,3-e][1,4]diazepines Francis J. Tinney, Joseph P. Sanchez, and Joan A. Nogas pp 624 - 630; DOI: 10.1021/jm00252a011 |
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Potential antitumor agents. 9. 2-Formyl(m-amino)phenylpyridine thiosemicarbazones Krishna C. Agrawal, Ai Jeng Lin, Barbara A. Booth, J. Randall Wheaton, and Alan C. Sartorelli pp 631 - 635; DOI: 10.1021/jm00252a012 |
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Synthesis and antiinflammatory activity of some 1-alkyl-4-phenylpyrido[2,3-d]pyrimidin-2(1H)-ones G. E. Hardtmann, B. Huegi, G. Koletar, S. Kroin, H. Ott, J. W. Perrine, and E. I. Takesue pp 636 - 639; DOI: 10.1021/jm00252a013 |
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Substituted azopurines. 1. Synthesis of 8,8'-dioxo-6,6'-azopurine Joseph R. Davis, Arun L. Jadhav, and Jawed Fareed pp 639 - 642; DOI: 10.1021/jm00252a014 |
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Synthesis and enzymic activity of 1,2,4-triazole-3-carboxamide 6'-deoxyhomoribonucleoside-6'-phosphonic acid and related compounds Mercedes Fuertes, Joseph T. Witkowski, David G. Streeter, and Roland K. Robins pp 642 - 645; DOI: 10.1021/jm00252a015 |
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3-Substituted 5,7-dimethylpyrazolo[1,5-a]pyrimidines, 3',5'-cyclic AMP phosphodiesterase inhibitors Thomas Novinson, Ruth Hanson, M. K. Dimmitt, Lionel N. Simon, Roland K. Robins, and Darrell E. O'Brien pp 645 - 648; DOI: 10.1021/jm00252a016 |
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Fibrin-stabilizing factor inhibitors. 11. Monodansylated weak aliphatic diamines Christine Ljunggren, Kurt J. Hoffmann, Pal Stenberg, Uno Svensson, J. Lars. G. Nilsson, Ann Hartkoorn, and Ragnar Lunden pp 649 - 651; DOI: 10.1021/jm00252a017 |
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10-Alkyl- and 10-aminoalkyl-2,2'-bis(trifluoromethyl)-3,10'-biphenothiazines Kuppuswamy Nagarajan, Joy David, and Agasaladinni N. Goud pp 652 - 653; DOI: 10.1021/jm00252a018 |
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Microbial hydroxylation of acronycine D. R. Brannon, D. R. Horton, and Gordon H. Svoboda pp 653 - 654; DOI: 10.1021/jm00252a019 |
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4-(and 5-)(2-Thienyl)-1-naphthaleneacetic acids as antiinflammatory agents James S. Kaltenbronn and Tae O. Rhee pp 654 - 657; DOI: 10.1021/jm00252a020 |
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6-Phenyl-6-propionoxyperhydrobenzo[c]quinolizines as potential analgetics M. E. Rogers and J. Sam pp 657 - 659; DOI: 10.1021/jm00252a021 |
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Total synthesis of the antitumor antibiotic daunorubicin. Coupling of the sugar and aglycone Edward M. Acton, Allan N. Fujiwara, and David W. Henry pp 659 - 660; DOI: 10.1021/jm00252a022 |
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Book Reviews pp 660 - 660; DOI: 10.1021/jm00252a600 |
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Quantitative structure-activity relation of reversible dihydrofolate reductase inhibitors. Diaminotriazines Corwin Hansch and Carlo Silipo pp 661 - 667; DOI: 10.1021/jm00253a001 |
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Potential bioreductive alkylating agents. 4. Inhibition of coenzyme Q enzyme systems by lipoidal benzoquinone and naphthoquinone derivatives Ai Jen Lin, Ronald S. Pardini, Brian J. Lillis, and Alan C. Sartorelli pp 668 - 672; DOI: 10.1021/jm00253a002 |
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Cysteine scavengers. 2. Synthetic .alpha.-methylenebutyrolactones as potential tumor inhibitors Andre Rosowsky, Nickolas Papathanasopoulos, Herbert Lazarus, George E. Foley, and Edward J. Modest pp 672 - 676; DOI: 10.1021/jm00253a003 |
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Potential antimalarials. 8. 10-Substituted 9-phenanthrenemethanols Lee C. Washburn and D. E. Pearson pp 676 - 682; DOI: 10.1021/jm00253a004 |
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Synthesis of analogs of 6-arylthio-, 6-arylsulfinyl-, and 6-arylsulfonyl-2,4-diaminoquinazolines as potential antimalarial agents John B. Hynes, Wallace T. Ashton, Hugh G. Merriman, and Flornoy C. Walker pp 682 - 684; DOI: 10.1021/jm00253a005 |
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Quinoline derivatives as antiallergy agents Charles M. Hall, Herbert G. Johnson, and John B. Wright pp 685 - 690; DOI: 10.1021/jm00253a006 |
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D-(R)- and L-(S)-3-Alkylaminopyrrolidino-substituted dihydrodibenzo[b,f]- and -[b,e]thiepins, xanthenes, and diphenylmethanes Donald T. Witiak, Song Y. Hsu, James E. Ollmann, Robert K. Griffith, Shiv K. Seth, and Michael C. Gerald pp 690 - 696; DOI: 10.1021/jm00253a007 |
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Synthesis of L-1-deoxyfluoroglycerol and its 3-phosphate ester. Effects of the L and D enantiomers in BDF1 mice Thomas P. Fondy, Richard W. Pero, Katherine L. Karker, Gurdev S. Ghangas, and Frederick H. Batzold pp 697 - 702; DOI: 10.1021/jm00253a008 |
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Amine functions of reduced basicity. Hypoglycemic and natriuretic .alpha.-alkoxybenzylamidoximes, amidines, and cycloamidines Denis M. Bailey, C. George DeGrazia, David Wood, James Siggins, Homer R. Harding, Gordon O. Potts, and Thomas W. Skulan pp 702 - 708; DOI: 10.1021/jm00253a009 |
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Blood glucose lowering sulfonamides with asymmetric carbon atoms. 1 C. Rufer, H. Biere, H. Ahrens, O. Loge, and E. Schroeder pp 708 - 715; DOI: 10.1021/jm00253a010 |
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Blood glucose lowering sulfonamides with asymmetric carbon atoms. 2 H. Biere, C. Rufer, H. Ahrens, O. Loge, and E. Schroeder pp 716 - 721; DOI: 10.1021/jm00253a011 |
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Hypolipidemic substituted 1,3-benzodioxole-2-carboxylates J. Martin Grisar, George P. Claxton, Roger A. Parker, Frank P. Palopoli, and Takashi Kariya pp 721 - 725; DOI: 10.1021/jm00253a012 |
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3-Aryl-3-hydroxyquinolizidines with potential hypotensive, antidepressant, and analgetic activity M. E. Rogers, Joseph Sam, and N. P. Plotnikoff pp 726 - 729; DOI: 10.1021/jm00253a013 |
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Structure-activity relations of the mitomycins and certain synthetic analogs William A. Remers and Cynthia S. Schepman pp 729 - 732; DOI: 10.1021/jm00253a014 |
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Analgesics. 1. Selected 5-substituted 5-propionoxybarbituric acids Julius A. Vida, Carlos M. Samour, Mary H. O'Dea, Theodore S. T. Wang, William R. Wilber, and John F. Reinhard pp 732 - 736; DOI: 10.1021/jm00253a015 |
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Benzamidopiperidines. 2. Heterocyclic compounds related to indoramin John L. Archibald and Gerald A. Benke pp 736 - 739; DOI: 10.1021/jm00253a016 |
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Benzamidopiperidines. 3. Carbocyclic derivatives related to indoramin John L. Archibald, Paula Fairbrother, and John L. Jackson pp 739 - 744; DOI: 10.1021/jm00253a017 |
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1,4-Bis(2-indol-3-ylethyl)piperazines John L. Archibald and Meier E. Freed pp 745 - 747; DOI: 10.1021/jm00253a018 |
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Chemical conversion of the psychotomimetic amine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane to 5-hydroxy-2,6-dimethylindole Jonathan S. Zweig and Neal Castagnoli pp 747 - 749; DOI: 10.1021/jm00253a019 |
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Quantum statistical calculation for the correlation of biological activity and chemical structure. 2. Drug-membrane penetrations Teng K. Lin pp 749 - 751; DOI: 10.1021/jm00253a020 |
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Quantum statistical calculation for the correlation of biological activity and chemical structure. 3. Disopyramide phosphate and related compounds as antiarrhythmic agents Teng K. Lin, Y. W. Chien, R. R. Dean, J. E. Dutt, H. W. Sause, C. H. Yen, and P. K. Yonan pp 751 - 753; DOI: 10.1021/jm00253a021 |
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Quantitative structure-activity analysis in a series of antimycotically active N-hydroxypyridones Walter Dittmar, Eike Druckrey, and Hansjoerg Urbach pp 753 - 756; DOI: 10.1021/jm00253a022 |
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Nitrofurans with high renal excretion Eva B. Akerblom pp 756 - 758; DOI: 10.1021/jm00253a023 |
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Potential anticancer agents. 10. Synthesis of N-[4-[[(2,4-diamino-7-pteridyl)methyl]-N10-methylamino]benzoyl)glutamic acid Dan C. Suster, Liviu V. Feyns, Gheorghe Ciustea, Georgeta Botez, Vasile Dobre, Ralph Bick, and Ion Niculescu-Duvaz pp 758 - 760; DOI: 10.1021/jm00253a024 |
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In vitro and in vivo activity of certain thiosemicarbazones against Trypanosoma cruzi H. Robert Wilson, Ganapathi R. Revankar, and Richard L. Tolman pp 760 - 761; DOI: 10.1021/jm00253a025 |
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Potential antileprotic agents. 3. Inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines J. I. DeGraw, V. H. Brown, W. T. Colwell, and N. E. Morrison pp 762 - 764; DOI: 10.1021/jm00253a026 |
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Thymidine 5' variants as inhibitors of thymidylate kinase J. J. Baker, P. Mellish, C. Riddle, A. R. Somerville, and J. R. Tittensor pp 764 - 766; DOI: 10.1021/jm00253a027 |
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3-Onium derivatives of 1,4-benzodiazepin-2-ones with tertiary organic bases T. Kovac, F. Kajfez, V. Sunjic, and M. Oklobdzija pp 766 - 769; DOI: 10.1021/jm00253a028 |
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Formation of germine 3,15-diacetate via the isomerization of germine 3,16-diacetate Edward M. Cohen, Rezso Aczel, Mary L. Torchiana, Roger Tull, and Edward J. J. Grabowski pp 769 - 770; DOI: 10.1021/jm00253a029 |
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Polymeric salicylate derivatives Abraham Havron, Ben-Z. Weiner, and Albert Zilkha pp 770 - 772; DOI: 10.1021/jm00253a030 |
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Immunosuppressive and antiinflammatory activities of cinanserin and its analogs Robert C. Millonig, Blanche J. Amrein, Joel Kirschbaum, and Sidney M. Hess pp 772 - 775; DOI: 10.1021/jm00253a031 |
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Antiparasitic thiocyanatobenzothiazoles Robert J. Alaimo, Stanford S. Pelosi, Christopher J. Hatton, and Joseph E. Gray pp 775 - 776; DOI: 10.1021/jm00253a032 |
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Optimization of alkyl modifications by Fibonacci search Thomas M. Bustard pp 777 - 778; DOI: 10.1021/jm00253a033 |
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Preparation of morphine-6-3H and its isotopic stability in man and in rat Jack Fishman, Baiba Norton, Mary L. Cotter, and Elliot F. Hahn pp 778 - 781; DOI: 10.1021/jm00253a034 |
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Synthesis and some pharmacological properties of 8-L-homoarginine-vasopressin and of 1-deamino-8-L-homoarginine-vasopressin Gunnar Lindeberg, Miklos Bodanszky, Margot Acosta, and Wilbur H. Sawyer pp 781 - 783; DOI: 10.1021/jm00253a035 |
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Book Reviews pp 783 - 784; DOI: 10.1021/jm00253a600 |
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Boron hydride derivatives for neutron capture therapy. Antibody approach Hou S. Wong, Eugene I. Tolpin, and William N. Lipscomb pp 785 - 791; DOI: 10.1021/jm00254a001 |
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Binding studies of boron hydride derivatives to proteins for neutron capture therapy Eugene I. Tolpin, Hou S. Wong, and William N. Lipscomb pp 792 - 796; DOI: 10.1021/jm00254a002 |
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Protein-binding polyhedral boranes. 1 R. L. Sneath, A. H. Soloway, and A. S. Dey pp 796 - 799; DOI: 10.1021/jm00254a003 |
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Application of the sequential simplex method in designing drug analogs Ferenc Darvas pp 799 - 804; DOI: 10.1021/jm00254a004 |
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Conformational analysis of acridan derivatives by nuclear magnetic resonance spectroscopy. Relation between conformation and pharmacological activity Manvendra B. Shambhu, R. Rao Koganty, and George A. Digenis pp 805 - 809; DOI: 10.1021/jm00254a005 |
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Hydrogen bond breaking potency of fluorocarbon anesthetics Therese Di Paolo and C. Sandorfy pp 809 - 814; DOI: 10.1021/jm00254a006 |
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Theoretical approach to structure-activity relations of chloramphenicol and congeners Hans D. Hoeltje and Lemont B. Kier pp 814 - 819; DOI: 10.1021/jm00254a007 |
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.beta.-Amino ketones. Synthesis and some biological activities in mice of 3,3-dialkyl-1,2,3,4-tetrahydro-4-quinolinones and related Mannich bases Aspi B. Daruwala, James E. Gearien, William J. Dunn, Phillipe S. Benoit, and Ludwig Bauer pp 819 - 824; DOI: 10.1021/jm00254a008 |
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Antifungal activity of bischelates of 5-, 7-, and 5,7-halogenated 8-quinolinols with copper(II). Determination of approximate dimensions of the long and short axes of the pores in the fungal spore wall Herman Gershon pp 824 - 827; DOI: 10.1021/jm00254a009 |
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Antiviral agents. Chemical modifications of a disulfide antibiotic, acetylaranotin K. C. Murdock pp 827 - 835; DOI: 10.1021/jm00254a010 |
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Structure and antischistosomal activity in the nitrofurylvinyl and the niridazole series. Noninterchangeability of the nitroheterocyclic rings Youlin Lin, Peter B. Hulbert, Ernest Bueding, and Cecil H. Robinson pp 835 - 840; DOI: 10.1021/jm00254a011 |
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Synthesis of alkyl-substituted .alpha.,.beta.-unsaturated .gamma.-lactones as potential antitumor agents Gary A. Howie, Peter E. Manni, and John M. Cassady pp 840 - 843; DOI: 10.1021/jm00254a012 |
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Hypothalamic hormones. 54. Synthesis and some biological activities of substance P George H. Fisher, John Humphries, Karl Folkers, Bengt Pernow, and Cyril Y. Bowers pp 843 - 846; DOI: 10.1021/jm00254a013 |
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Synthesis and hypocholesterolemic activities of eritadenine derivatives Kentaro Okumura, Kazuo Matsumoto, Masaharu Fukamizu, Harunori Yasuo, Yoshihiko Taguchi, Yukio Sugihara, Ichizo Inoue, Masahiko Seto, Yasuhiko Sato, and et al. pp 846 - 855; DOI: 10.1021/jm00254a014 |
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Binding to deoxyribonucleic acid and inhibition of ribonucleic acid polymerase by analogs of chloroquine Victor E. Marquez, Joseph W. Cranston, Raymond W. Ruddon, and Joseph H. Burckhalter pp 856 - 862; DOI: 10.1021/jm00254a015 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine Ronald T. Borchardt and Yih Shiong Wu pp 862 - 868; DOI: 10.1021/jm00254a016 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine Ronald T. Borchardt, Joan A. Huber, and Yih Shiong Wu pp 868 - 873; DOI: 10.1021/jm00254a017 |
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Four cyclic disulfide pentapeptides possessing the ring of isotocin and glumitocin Clark W. Smith, Victor J. Hruby, and Martha F. Ferger pp 873 - 876; DOI: 10.1021/jm00254a018 |
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Stereochemical aspects and metabolite formation in the in vivo metabolism of the psychotomimetic amine, 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane S. B. Matin, P. S. Callery, J. S. Zweig, A. O'Brien, R. Rapoport, and N. Castagnoli pp 877 - 882; DOI: 10.1021/jm00254a019 |
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Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene Edwin R. Andrews, Robert W. Fleming, J. Martin Grisar, James C. Kihm, David L. Wenstrup, and Gerald D. Mayer pp 882 - 886; DOI: 10.1021/jm00254a020 |
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Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones William L. Albrecht, Robert W. Fleming, Stephen W. Horgan, James C. Kihm, and Gerald D. Mayer pp 886 - 889; DOI: 10.1021/jm00254a021 |
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Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 4. Bis basic sulfonamides of anthraquinone J. Martin Grisar, Kenneth R. Hickey, Robert W. Fleming, and Gerald D. Mayer pp 890 - 893; DOI: 10.1021/jm00254a022 |
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Coenzyme Q. 167. Antimetabolites of coenzyme Q. 19. Synthesis and bioassays of new dimethoxyalkylmercapto-1,4-benzoquinones Ronald J. Wikholm, Yoshifumi Iwamoto, Conny B. Bogentoft, Thomas H. Porter, and Karl Folkers pp 893 - 896; DOI: 10.1021/jm00254a023 |
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Antineoplastic agents. 36. Acetylenic carrier groups George R. Pettit and Edris I. Saldana pp 896 - 898; DOI: 10.1021/jm00254a024 |
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Quantitative reexamination of structure-activity relations in the .DELTA.6-6-substituted progesterone series Manfred E. Wolff and Corwin Hansch pp 898 - 900; DOI: 10.1021/jm00254a025 |
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Radioprotective activity of p-aminopropiophenone. Structure-activity investigation Thomas J. Fitzgerald, John Doull, and Frederick G. DeFeo pp 900 - 902; DOI: 10.1021/jm00254a026 |
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Synthesis of seleno-toluidine blue John T. Groves, S. Martin Lindenauer, B. J. Haywood, J. A. Knol, and Jerome S. Schultz pp 902 - 904; DOI: 10.1021/jm00254a027 |
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Centrally acting muscle relaxants. Isomeric 9,10-dihydroxy-1,2,3,4,4a,9,10,10a(trans-4a,10a)-octahydrophenanthrenes and their carbamate esters Wendel L. Nelson and Bob E. Sherwood pp 904 - 907; DOI: 10.1021/jm00254a028 |
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Importance of the nitrogen lone electron pair orientation in stereospecific opiates B. Belleau, T. Conway, F. R. Ahmed, and A. D. Hardy pp 907 - 908; DOI: 10.1021/jm00254a029 |
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Clastic binding on the opiate receptor B. Belleau and P. Morgan pp 908 - 909; DOI: 10.1021/jm00254a030 |
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Book Reviews pp 910 - 910; DOI: 10.1021/jm00254a600 |
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Prostaglandin nomenclature Norman A. Nelson pp 911 - 918; DOI: 10.1021/jm00255a001 |
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Chemoimmunotherapy of cancer. 1 A. H. Soloway, I. Agranat, A. R. Chase, R. E. Hernandez, E. S. Kimball, T. Cascieri, and C. H. Cox pp 918 - 922; DOI: 10.1021/jm00255a002 |
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Potential antitumor agents. 14. Acridylmethanesulfonanilides Bruce F. Cain, Ralph N. Seelye, and Graham J. Atwell pp 922 - 930; DOI: 10.1021/jm00255a003 |
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Potential antitumor agents. 15. Bisquaternary salts Graham J. Atwell and Bruce F. Cain pp 930 - 934; DOI: 10.1021/jm00255a004 |
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Potential antitumor agents. 11. Inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines Krishna C. Agrawal, Men H. Lee, Barbara A. Booth, E. Colleen Moore, and Alan C. Sartorelli pp 934 - 938; DOI: 10.1021/jm00255a005 |
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Conformational requirements of substrate and inhibitor on acetylcholinesterase George H. Cocolas, J. Gregory Cranford, and Hye Sook Choi pp 938 - 943; DOI: 10.1021/jm00255a006 |
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Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminoquinazolines and related compounds W. E. Richter and J. J. McCormack pp 943 - 947; DOI: 10.1021/jm00255a007 |
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Rifamycin derivatives as inhibitors of a ribonucleic acid instructed deoxyribonucleic acid polymerase function. Effect of lipophilicity Allan N. Tischler, Frances M. Thompson, Louis J. Libertini, and Melvin Calvin pp 948 - 952; DOI: 10.1021/jm00255a008 |
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Glycoside cleavage reactions on erythromycin A. Preparation of erythronolide A Ronald A. LeMahieu, Mathew Carson, Richard W. Kierstead, Lucy M. Fern, and E. Grunberg pp 953 - 956; DOI: 10.1021/jm00255a009 |
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Hantzsch-type dihydropyridine hypotensive agents Bernard Loev, Marjorie M. Goodman, Kenneth M. Snader, Ralph Tedeschi, and Edward Macko pp 956 - 965; DOI: 10.1021/jm00255a010 |
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Bis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 5. Bis-basic ethers of anthraquinone and bisalkamine esters of anthraquinonedicarboxylic acids Arthur D. Sill, Edwin R. Andrews, F. William Sweet, Jake W. Hoffman, Paul L. Tiernan, J. Martin Grisar, Robert W. Fleming, and Gerald D. Mayer pp 965 - 968; DOI: 10.1021/jm00255a011 |
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[1-.beta.-Mercapto-.beta.,.beta.-diethylpropionic acid, 4-leucine]-8-lysine-vasopressin and [1-.beta.-mercapto-.beta.,.beta.-diethylpropionic acid, 4-leucine]oxytocin, compounds possessing antihormonal properties Douglas F. Dyckes, John J. Nestor, Martha F. Ferger, Vincent Du Vigneaud, and W. Y. Chan pp 969 - 972; DOI: 10.1021/jm00255a012 |
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Amodiaquine analogs. Synthesis of 6-(N,N-diethylamino)methyl-4-hydroxy]anilino]-5,8-dimethoxy-2,4-dimethylquinoline and related compounds Carroll Temple, Jerry D. Rose, and John A. Montgomery pp 972 - 977; DOI: 10.1021/jm00255a013 |
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Synthesis and antimicrobial activity of aliphatic nitro compounds Nigel G. Clark, Betty Croshaw, Brian E. Leggetter, and David F. Spooner pp 977 - 981; DOI: 10.1021/jm00255a014 |
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Reinvestigation of a nonadditive quantitative structure-activity relation Arthur Cammarata and Thomas M. Bustard pp 981 - 985; DOI: 10.1021/jm00255a015 |
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Carbon-13 magnetic resonance study. Structure of the metabolites of orally administered quinidine in humans F. I. Carroll, Doris Smith, Monroe E. Wall, and Charles G. Moreland pp 985 - 987; DOI: 10.1021/jm00255a016 |
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Stereochemistry and absolute configuration of the analgesic agonist-antagonist (-)-5-m-hydroxyphenyl-2-methylmorphan Todd G. Cochran pp 987 - 989; DOI: 10.1021/jm00255a017 |
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Stereochemical studies on medicinal agents. 18. Absolute configuration and analgetic potency of trimeperidine enantiomers David Fries and Philip S. Portoghese pp 990 - 993; DOI: 10.1021/jm00255a018 |
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Structural modification study of the antimalarial 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran Daniel J. McCaustland, Ping-Lu Chien, William H. Burton, and C. C. Cheng pp 993 - 1000; DOI: 10.1021/jm00255a019 |
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Synthesis of some N-carboxylic acid derivatives of 3-phenoxypyrrolidines, 4-phenoxypiperidines, and 3-phenoxynortropanes with muscle relaxant and anticonvulsant activities Robert F. Boswell, Grover C. Helsley, Robert L. Duncan, William H. Funderburk, and David N. Johnson pp 1000 - 1008; DOI: 10.1021/jm00255a020 |
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Antihypertensive activity of 1-dimethylphosphinylmethyl-4-arylpiperazines Edward J. Glamkowski, Joseph Strupczewski, Erhard Wolf, and David L. Woodward pp 1008 - 1009; DOI: 10.1021/jm00255a021 |
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Antimalarials. 3. Fluorenemethanols Edward R. Atkinson and Felix E. Granchelli pp 1009 - 1012; DOI: 10.1021/jm00255a022 |
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Antimalarials. 4. Tetrahydroquinolinemethanols Edward R. Atkinson pp 1012 - 1013; DOI: 10.1021/jm00255a023 |
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Antineoplastic agents. 34. Helenium autumnale George R. Pettit, John C. Budzinski, Gordon M. Cragg, Peter Brown, and LaRea D. Johnston pp 1013 - 1016; DOI: 10.1021/jm00255a024 |
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Synthesis and biological activities of analogs of the luteinizing hormone-releasing hormone (LH-RH) modified in position 2 Richard W. A. Rees, Theodore J. Foell, Sie-Yearl Chai, and Norman Grant pp 1016 - 1019; DOI: 10.1021/jm00255a025 |
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Synthesis and antiprotozoal activity of 1-(3-chloro-2-hydroxypropyl)-substituted nitroimidazoles Max Hoffer and Emanuel Grunberg pp 1019 - 1020; DOI: 10.1021/jm00255a026 |
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Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline Patrick E. Hanna, Vernon R. Grund, and M. W. Anders pp 1020 - 1023; DOI: 10.1021/jm00255a027 |
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Quinazolines as inhibitors of dihydrofolate reductase. 2 John B. Hynes, Wallace T. Ashton, Dale Bryansmith, and James H. Freisheim pp 1023 - 1025; DOI: 10.1021/jm00255a028 |
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Mesoionic purinone analogs. 7. In vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo[3,2,-a]pyrimidine-5,7-diones Robert A. Coburn, Richard A. Glennon, and Zdzislaw F. Chmielewicz pp 1025 - 1027; DOI: 10.1021/jm00255a029 |
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Synthesis of the .alpha. and .beta. anomers of 1-(2-deoxy-D-ribofuranosyl)-4-pyridone Warren J. Woodford, Barbara A. Swartz, Conrad J. Pillar, Arieh Kampf, and Mathias P. Mertes pp 1027 - 1029; DOI: 10.1021/jm00255a030 |
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Single-step phosphorylation of 5-fluoro-2'-deoxyuridine to 5-fluoro-2'-deoxyuridine 5'-phosphate Tony M. K. Chiu and R. Bruce Dunlap pp 1029 - 1030; DOI: 10.1021/jm00255a031 |
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Synthesis and biological properties of 6'-amino-6'-deoxygentamicin A Tattanahalli L. Nagabhushan and Peter J. L. Daniels pp 1030 - 1031; DOI: 10.1021/jm00255a032 |
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3-Hydroxy-1-nitrophenyl-1H-pyrazolo[3,4-b]pyridines as selective inhibitors of rat liver xanthine oxidase Surendra S. Parmar, B. R. Pandey, C. Dwivedi, and Basheer Ali pp 1031 - 1033; DOI: 10.1021/jm00255a033 |
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Cycloserine carbamates Jimmie D. Weaver, Neal F. Busch, and Charles H. Stammer pp 1033 - 1035; DOI: 10.1021/jm00255a034 |
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Book Reviews pp 1036 - 1036; DOI: 10.1021/jm00255a600 |
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Crystal structures of analgesics. Hydrochlorides of (-)-isomethadone, .alpha.-methadol, and .alpha.-methadyl acetate Eli Shefter pp 1037 - 1040; DOI: 10.1021/jm00256a001 |
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In pursuit of analgetic agents. Hydro-1,3-ethanoindeno[2,1-c]pyridines and homologs Robert L. Clarke, Anthony J. Gambino, and Sol J. Daum pp 1040 - 1046; DOI: 10.1021/jm00256a002 |
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Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide Willem F. M. Van Bever, Carlos J. E. Niemegeers, and Paul A. J. Janssen pp 1047 - 1051; DOI: 10.1021/jm00256a003 |
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Potential nonequilibrium analgetic receptor inactivators. Further pharmacologic studies of N-acylanileridines A. E. Takemori, Allen Ward, P. S. Portoghese, and V. G. Telang pp 1051 - 1054; DOI: 10.1021/jm00256a004 |
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Chemistry and pharmacology of apoise. 7. Susceptibility of some branched-chain sugar nucleosides to enzymic deamination Jean M. J. Tronchet, Jeannine Tronchet, and Rene Graf pp 1055 - 1056; DOI: 10.1021/jm00256a005 |
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Stereoisomeric lactoyl-.beta.-methylcholine iodides. Interaction with cholinesterase and acetylcholinesterase M. M.-L. Chan and J. B. Robinson pp 1057 - 1060; DOI: 10.1021/jm00256a006 |
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Luteinizing hormone-releasing hormone and analogs. Synthesis and biological activity Hans Immer, Vern R. Nelson, Clara Revesz, Kazimir Sestanj, and Manfred Goetz pp 1060 - 1065; DOI: 10.1021/jm00256a007 |
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Mercaptopyridinecarboxylic acids. Synthesis and hypoglycemic activity Benjamin Blank, Nicholas W. DiTullio, Clara K. Miao, Franklin F. Owings, John G. Gleason, Stephen T. Ross, Charles E. Berkoff, Harry L. Saunders, J. Delarge, and C. L. Lapiere pp 1065 - 1071; DOI: 10.1021/jm00256a008 |
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Adrenergic agents. 2. Synthesis and potential .beta.-adrenergic agonist activity of some ring-chlorinated relatives of isoproterenol Carl Kaiser, Donald F. Colella, Alex M. Pavloff, and Joe R. Wardell pp 1071 - 1075; DOI: 10.1021/jm00256a009 |
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Pyrimidine nucleosides. 6. Synthesis and anticancer activities of N4-substituted 2,2'-anhydronucleosides Tadashi Kanai, Motonobu Ichino, Akio Hoshi, Fumihiko Kanzawa, and Kazuo Kuretani pp 1076 - 1078; DOI: 10.1021/jm00256a010 |
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Synthesis, in vivo effects, metabolism, and excretion of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in the beagle dog George J. Ikeda, Charles B. Estep, Leo H. Wiemeler, and Arthur Alter pp 1079 - 1082; DOI: 10.1021/jm00256a011 |
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Anticoccidial agents. 1. Synthesis and anticoccidial activity of 4-deoxypyridoxol and its esters Yasuhiro Morisawa, Mitsuru Kataoka, Taiichiro Watanabe, Noritoshi Kitano, and Toshiaki Matsuzawa pp 1083 - 1086; DOI: 10.1021/jm00256a012 |
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Synthesis and biological activity of some aporphine derivatives related to apomorphine Walfred S. Saari, Stella W. King, Victor J. Lotti, and Alexander Scriabine pp 1086 - 1090; DOI: 10.1021/jm00256a013 |
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Aporphines. 11. Synthesis and dopaminergic activity of monohydroxyaporphines. Total synthesis of (+-)-11-hydroxyaporphine, (+-)-11-hydroxynoraporphine, and (+-)-11-hydroxy-N-propylnoraporphine John L. Neumeyer, Felix E. Granchelli, K. Fuxe, U. Ungerstedt, and H. Corrodi pp 1090 - 1095; DOI: 10.1021/jm00256a014 |
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Synthesis and antimalarial evaluation of 9,10-dihydrophenanthrene amino alcohols Adrienne S. Dey and John L. Neumeyer pp 1095 - 1100; DOI: 10.1021/jm00256a015 |
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Structure-activity relations in psychotomimetic phenylalkylamines F. A. B. Aldous, B. C. Barrass, K. Brewster, D. A. Buxton, D. M. Green, R. M. Pinder, P. Rich, M. Skeels, and K. J. Tutt pp 1100 - 1111; DOI: 10.1021/jm00256a016 |
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3-[.alpha.-(tert-Butylamino)methyl]-5-hydroxy-m-xylene-.alpha.,.alpha.'-diol, a selective bronchodilator Charles F. Schwender, Brooks R. Sunday, John Shavel, and Ralph E. Giles pp 1112 - 1115; DOI: 10.1021/jm00256a017 |
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Isosteres of natural phosphates. 3. Synthesis of the dilithium salt of 4,4-diethoxy-3-hydroxybutyl-1-phosphonic acid, an isostere of glyceraldehyde 3-phosphate Stephen L. Goldstein, Maria Pulcrano, Burton E. Tropp, and Robert Engel pp 1115 - 1117; DOI: 10.1021/jm00256a018 |
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14-Hydroxycodeinone. Improved synthesis Frank M. Hauser, Tek-Kuei Chen, and Frank I. Carroll pp 1117 - 1117; DOI: 10.1021/jm00256a019 |
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2-Aryl-3-dimethylphosphinylpropionic acids as potential nonsteroidal antiinflammatory agents V. Brian Anderson, Richard C. Allen, Jeffrey C. Wilker, and William J. Novick pp 1117 - 1118; DOI: 10.1021/jm00256a020 |
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N.omega.-(2-Mercaptoethyl) derivatives of ornithine and lysine as antiradiation agents James R. Piper, Lucy M. Rose, Anne G. Laseter, Thomas P. Johnston, and Marie M. Grenan pp 1119 - 1120; DOI: 10.1021/jm00256a021 |
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Synthesis of dl-3-(hydroxymethyl)tyrosine Theodore S. T. Wang and Julius A. Vida pp 1120 - 1122; DOI: 10.1021/jm00256a022 |
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Amino-imino tautomerism in the antibiotic formycin A as studied by CNDO/2 molecular orbital theory Gerald P. Ceasar and James J. Greene pp 1122 - 1124; DOI: 10.1021/jm00256a023 |
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Application of regular solution theory to biomembranes Lorna J. Bennett and Keith W. Miller pp 1124 - 1125; DOI: 10.1021/jm00256a024 |
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Annelated thyroxine analogs Michael T. Cox, W. Gary Bowness, and Jim J. Holohan pp 1125 - 1127; DOI: 10.1021/jm00256a025 |
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Potential antifertility agents. 5. 2,3-Diphenyl-1-(N-methyl-N-propargyl)aminoindenes R. R. Crenshaw, Thomas A. Jenks, and Gabriel Bialy pp 1127 - 1128; DOI: 10.1021/jm00256a026 |
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Book Reviews pp 1129 - 1130; DOI: 10.1021/jm00256a600 |
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Compounds related to 4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide. Synthesis and antiarrhythmic activity Chung H. Yen, Harman S. Lowrie, and Richard R. Dean pp 1131 - 1135; DOI: 10.1021/jm00257a001 |
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Synthesis, stereochemistry, and antiarrhythmic activity of some 8-substituted decahydroisoquinolines Ian W. Mathison and Phillip H. Morgan pp 1136 - 1139; DOI: 10.1021/jm00257a002 |
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Pyrrolo[4,3,2-de]isoquinolines with central nervous system and antihypertensive activities Christopher A. Demerson, Adolph H. Philipp, Leslie G. Humber, Michael J. Kraml, Marie P. Charest, Helen Tom, and Ivan Vavra pp 1140 - 1145; DOI: 10.1021/jm00257a003 |
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Potential antitumor agents. 10. Synthesis and biochemical properties of 5-N-alkylamino-, N,N-dialkylamino-, and N-alkylacetamido-1-formylisoquinoline thiosemicarbazones Paul D. Mooney, Barbara A. Booth, E. Colleen Moore, Krishna C. Agrawal, and Alan C. Sartorelli pp 1145 - 1150; DOI: 10.1021/jm00257a004 |
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Bis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 6. Bis-basic-substituted fluoranthenes William L. Albrecht, Robert W. Fleming, Stephen W. Horgan, Barbara A. Deck, Jake W. Hoffmann, and Gerald D. Mayer pp 1150 - 1156; DOI: 10.1021/jm00257a005 |
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Agonist and antagonist relations in 1- and 8-substituted analogs of angiotensin II Mahesh C. Khosla, Madeline M. Hall, Robert R. Smeby, and F. Merlin Bumpus pp 1156 - 1160; DOI: 10.1021/jm00257a006 |
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Structure-activity relations in immunochemistry. 2. Inhibition of complement by benzamidines Corwin Hansch and Masafumi Yoshimoto pp 1160 - 1167; DOI: 10.1021/jm00257a007 |
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Imidazole derivatives as inhibitors of cyclic nucleotide phosphodiesterases Russell Buchman, Peter F. Heinstein, and Jack N. Wells pp 1168 - 1173; DOI: 10.1021/jm00257a008 |
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Inhibition of tyrosinase-catalyzed melanin formation by catechol phenyl sulfones Jerome F. Siuda and Ayman Habal pp 1173 - 1177; DOI: 10.1021/jm00257a009 |
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Nonsteroidal antiinflammatory agents. 1. 2,4-Diphenylthiazole-5-acetic acid and related compounds Kevan Brown, David P. Cater, John F. Cavalla, David Green, Robert A. Newberry, and Alan B. Wilson pp 1177 - 1181; DOI: 10.1021/jm00257a010 |
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Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles Joseph G. Lombardino and Edward H. Wiseman pp 1182 - 1188; DOI: 10.1021/jm00257a011 |
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1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics N. J. Harper, G. B. A. Veitch, and D. G. Wibberley pp 1188 - 1193; DOI: 10.1021/jm00257a012 |
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Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids Julius A. Vida, Carlos M. Samour, Mary H. O'Dea, Theodore S. T. Wang, and John F. Reinhard pp 1194 - 1197; DOI: 10.1021/jm00257a013 |
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Analogs of 5'-deoxy-5'-(methylthio)adenosine John A. Montgomery, Anita T. Shortnacy, and H. Jeanette Thomas pp 1197 - 1207; DOI: 10.1021/jm00257a014 |
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Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs Michael Chaykovsky, Andre Rosowsky, Nickolas Papathanasopoulos, Katherine K. N. Chen, Edward J. Modest, Roy L. Kisliuk, and Yvette Gaumont pp 1212 - 1216; DOI: 10.1021/jm00257a015 |
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Quinazolines. 12. 1,3-Diaminobenzo[f]quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents Andre Rosowsky, Ping C. Huang, Nickolas Papathanasopoulos, and Edward J. Modest pp 1217 - 1222; DOI: 10.1021/jm00257a016 |
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Synthesis and biological activity of DL-3-(5-benzimidazolyl)-2-methylalanine Nicolas Zenker, Victor H. Morgenroth, and Jeremy Wright pp 1223 - 1225; DOI: 10.1021/jm00257a017 |
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Synthesis of .alpha.-heterosubstituted nitrosamines. Novel test substances for cancer and mutagenesis research Dieter Seebach and Dieter Enders pp 1225 - 1227; DOI: 10.1021/jm00257a018 |
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Synthesis and pharmacology of homoarginine bradykinin analogs Max E. Safdy and Phyllis A. Lyons pp 1227 - 1228; DOI: 10.1021/jm00257a019 |
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Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones A. Walser and R. I. Fryer pp 1228 - 1230; DOI: 10.1021/jm00257a020 |
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.alpha.-(Ureidomethylene)lactones and derived 5-(hyroxyalkyl)uracils George H. Denny and Malcolm A. Ryder pp 1230 - 1231; DOI: 10.1021/jm00257a021 |
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Antihypertensives. 1. Syntheses of thiazino-, thiazepino-, and thiazoninoethylguanidines Lawrence D. Wise, Glenn C. Morrison, Katherine Egan, Michael A. Commarato, Gregory Kopia, and Edmund C. Lattime pp 1232 - 1234; DOI: 10.1021/jm00257a022 |
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Anticoccidial agents. 2. Synthesis and anticoccidial activity of pyridoxol analogs Yasuhiro Morisawa, Mitsuru Kataoka, Taiichiro Watanabe, Noritoshi Kitano, and Toshiaki Metsuzawa pp 1235 - 1237; DOI: 10.1021/jm00257a023 |
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Synthesis and metabolic behavior of the suggested active species of isophosphamide having cytostatic activity Akira Takamizawa, Saichi Matsumoto, Tsuyoshi Iwata, Yoshihiro Tochino, Ken Katagiri, Kenji Yamaguchi, and Osamu Shiratori pp 1237 - 1239; DOI: 10.1021/jm00257a024 |
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Nucleoside Peptides. 6. Synthesis of Certain N-[5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carbonyl]amino Acids Related to Naturally Occurring Intermediates in the Purine Biosynthetic Pathway Prem C. Srivastava, Robert W. Mancuso, Robert J. Rousseau, and Roland K. Robins pp 1207 - 1211; DOI: 10.1021/jm00257a600 |
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Book Reviews pp 1239 - 1240; DOI: 10.1021/jm00257a601 |
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Synthetic fibrinolytic agents. 1. N-Monoacyl, N-monoalkyl, and related bis(tetrahydroisoquinolines) Ronald L. Buchanan, Vilmars Sprancmanis, Thomas A. Jenks, R. R. Crenshaw, George M. Luke, Henry M. Holava, and Richard A. Partyka pp 1241 - 1248; DOI: 10.1021/jm00258a002 |
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Synthetic fibrinolytic agents. 2. Selected N-monosubstituted bis(tetrahydroisoquinolines) designed to possess enhanced bioavailability Ronald L. Buchanan, Vilmars Sprancmanis, Thomas A. Jenks, R. R. Crenshaw, and George M. Luke pp 1248 - 1253; DOI: 10.1021/jm00258a003 |
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Cycloalkanones. 4. Antifertility activity Iris H. Hall, Gerald L. Carlson, G. Shuford Abernethy, and Claude Piantadosi pp 1253 - 1257; DOI: 10.1021/jm00258a004 |
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Potential antifertility agents. 6. Synthesis and biological activities of optical isomers of 4.beta.-(p-methoxyphenyl)-2.beta.-methylcyclohexane-.alpha.-carboxylic acid and related compounds R. R. Crenshaw, Thomas A. Jenks, George M. Luke, and Gabriel Bialy pp 1258 - 1261; DOI: 10.1021/jm00258a005 |
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Potential antifertility agents. 7. Synthesis and biological activities of 2-, 3-, and 6-alkyl-substituted 4-aryl-2-methylcyclohexanecarboxylic acids R. R. Crenshaw, George M. Luke, Thomas A. Jenks, and Gabriel Bialy pp 1262 - 1268; DOI: 10.1021/jm00258a006 |
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Synthesis and antifolate activity of isoaminopterin M. G. Nair, L. P. Mercer, and Charles M. Baugh pp 1268 - 1272; DOI: 10.1021/jm00258a007 |
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Pyrimido[4,5-c]isoquinolines. 2. Synthesis and biological evaluation of some 6-alkyl-, 6-aralkyl-, and 6-aryl-1,3-diamino-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolines as potential folate antagonists Andre Rosowsky and Nickolas Papathanasopoulos pp 1272 - 1276; DOI: 10.1021/jm00258a008 |
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Synthesis of 6-(phenylhydrazino)uracils and their inhibition of a replication-specific deoxyribonucleic acid polymerase George E. Wright and Neal C. Brown pp 1277 - 1282; DOI: 10.1021/jm00258a009 |
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Synthesis and biological activity of selected 2-substituted 6-(.beta.-D-ribofuranosyl)oxazolo[5,4-d]pyrimidin-7-ones Vemanna D. Patil, Dean S. Wise, Leroy B. Townsend, and Alexander Bloch pp 1282 - 1285; DOI: 10.1021/jm00258a010 |
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Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S-tubercidinylhomocysteine James K. Coward, Donald L. Bussolotti, and Chi-Deu Chang pp 1286 - 1289; DOI: 10.1021/jm00258a011 |
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Enzyme inhibitors. Inhibition of brain choline acetyltransferase by derivatives of 4-styrylpyrimidine Raymond E. Gibson and B. R. Baker pp 1290 - 1293; DOI: 10.1021/jm00258a012 |
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Study of pituitary hormone analogs for their inhibitory properties and resistance to carboxamidopeptidases. [9-L-Proline]oxytocin, [9-L-glutamic acid]oxytocin, and [8-L-lysine,9-glycine methylamide]oxytocin Z. Grzonka, J. D. Glass, I. L. Schwartz, and Roderich Walter pp 1294 - 1298; DOI: 10.1021/jm00258a013 |
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Effect of lipophilic substituents on some biological properties of indoles Calvert W. Whitehead and Celia A. Whitesitt pp 1298 - 1304; DOI: 10.1021/jm00258a014 |
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Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA Michael W. Sundberg, Claude F. Meares, David A. Goodwin, and Carol I. Diamanti pp 1304 - 1307; DOI: 10.1021/jm00258a015 |
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Methotrexate analogs. 4. 7-Methyl derivatives of methotrexate and dichloromethotrexate. New synthesis and some biological studies Andre Rosowsky and Katherine K. N. Chen pp 1308 - 1311; DOI: 10.1021/jm00258a016 |
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Semisynthetic .beta.-lactam antibiotics. 6. Sulfocephalosporins and their antipseudomonal activities Hiroaki Nomura, Takeshi Fugono, Takenori Hitaka, Isao Minami, Toshiyuki Azuma, Shiro Morimoto, and Toru Masuda pp 1312 - 1315; DOI: 10.1021/jm00258a017 |
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Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type Eugene E. Galantay, Ronald Simpson, George Corriveau, Max Denzer, Douglas C. Knorr, Robert J. Strohschein, Nicholas A. Paolella, Yasuyuki Uike, John H. Gogerty, and et al. pp 1316 - 1327; DOI: 10.1021/jm00258a018 |
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Improved synthesis and additional pharmacology of the potent analgetic (-)-5-m-hydroxyphenyl-2-methylmorphan Michael E. Rogers and Everette L. May pp 1328 - 1330; DOI: 10.1021/jm00258a019 |
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Deuterium isotope effects in the in vivo metabolism of cotinine Ermias Dagne, Larry Gruenke, and Neal Castagnoli pp 1330 - 1333; DOI: 10.1021/jm00258a020 |
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Triarylhaloethylenes as gonadotropin inhibitors Frank P. Palopoli, Vernon J. Feil, Dorsey E. Holtkamp, and Alfred Richardson pp 1333 - 1335; DOI: 10.1021/jm00258a021 |
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Polymeric anions and biological activities. Effects on intramuscular and intraperitoneal Walker carcinosarcoma 256 of the rat Ernest M. Hodnett and Joseph T. H. Tai pp 1335 - 1337; DOI: 10.1021/jm00258a022 |
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Antiinflammatory sydnones. 1 H. Wagner and John B. Hill pp 1337 - 1338; DOI: 10.1021/jm00258a023 |
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Additions and Corrections - Thia Steroids. III Derivatives of 2-Thia-A-nor-5α-androstan-17β-ol as Probes of Steroid-Receptor Interactions. Manfred E. Wolff, Galal Zanati, G. Shanmugasundarum, Sharad Gupte, and Gunhild Aadahl pp 1339 - 1339; DOI: 10.1021/jm00258a600 |
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Additions and Corrections - Diamidino-α,ω-diphenoxyalkanes. Structure-Activity Relationships for the Inhibition of Thrombin, Pancreatic Kallikrein, and Trypsin. J. D. Geratz, Alan C. Whitmore, Michael C.-F. Cheng, and Claude Piantadosi pp 1339 - 1339; DOI: 10.1021/jm00258a601 |
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Additions and Corrections - "Aromatic" Substituent Constants for Structure-Activity Correlations. Corwin Hansch, Albert Leo, Stefan H. Unger, Ki Hwan Kim, Donald Nikaitani, and Eric J. Lien pp 1339 - 1339; DOI: 10.1021/jm00258a602 |
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Additions and Corrections - Strategy in Drug Design. Cluster Analysis as an Aid in the Selection of Substituents. Corwin Hansch, Stefan H. Unger, and Alan B. Forsythe pp 1339 - 1339; DOI: 10.1021/jm00258a603 |
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Additions and Corrections - Synthesis and Biological Activity of Some Analogs of the Gonadotropin Releasing Hormone. W. Arnold, G. Flouret, R. Morgan, R. Rippel, and W. White pp 1339 - 1339; DOI: 10.1021/jm00258a604 |
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Book Reviews pp 1339 - 1342; DOI: 10.1021/jm00258a605 |